Piperazine → 2-(Piperazin-1-yl)-6-(trifluoromethyl)benzonitrile

HRID 2113543Notes

Reaction equation

HRID 2113543 reaction equation
F[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[C:4]#[N:5].[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>O1CCOCC1>[C:4]([C:3]1[C:6]([C:10]([F:13])([F:12])[F:11])=[CH:7][CH:8]=[CH:9][C:2]=1[N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)#[N:5]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 1456132-Fluoro-6-(trifluoromethyl)benzonitrile

Product 1

HCID 231207342-(Piperazin-1-yl)-6-(trifluoromethyl)benzonitrile

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3 g (15.8 mmol) of 2-fluoro-6-trifluoromethylbenzonitrile, 7.5 g (87 mmol) of piperazine and 24 mL of dioxane is heated at reflux for 5 hours.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 5 hours

Sources & evidence

ORD record
ord-7754f89a01cb46aaa98ef25c7b6ba433
Source dataset
uspto-grants-2008_10
Patent number
US07432269B2

Reaction notes

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