HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Morpholinoethylamine → HCID 69315031, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Morpholinoethylamine | HCID 408285 | — |
| Reactant | 1,7-Naphthyridine-3-carbonitrile, 4-[(3-bromo-4-methylphenyl)amino]-6-fluoro- | HCID 69180814 | — |
| Product | HCID 69315031 | HCID 69315031 | 18% |
Reaction Steps
Following the procedure described above in Example 1, 4-[(3-bromo-4-methylphenyl)amino]-6-fluoro-[1,7]naphthyridine-3-carbonitrile (300 mg, 1.1 mmol, 1 eq) was reacted with 2-morpholin-4-yl-1-ethylamine (3 mL, 20 eq). The crude product was purified via preparative HPLC to obtain 67 mg product (18% yield):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432279B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-494a7ca19b734ed1b60570023d55b1d3 |
| Source note | uspto-grants-2008_10 |