2-Morpholinoethylamine → HCID 69315031, compound

HRID 2113594Notes

Reaction equation

HRID 2113594 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][N:16]=[C:17](F)[CH:18]=3)[N:13]=[CH:12][C:11]=2[C:21]#[N:22])[CH:5]=[CH:6][C:7]=1[CH3:8].[N:23]1([CH2:29][CH2:30][NH2:31])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][N:16]=[C:17]([NH:31][CH2:30][CH2:29][N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)[CH:18]=3)[N:13]=[CH:12][C:11]=2[C:21]#[N:22])[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 691808141,7-Naphthyridine-3-carbonitrile, 4-[(3-bromo-4-methylphenyl)amino]-6-fluoro-

Product 1

HCID 69315031HCID 69315031, compoundYield 18%

Procedure

Following the procedure described above in Example 1, 4-[(3-bromo-4-methylphenyl)amino]-6-fluoro-[1,7]naphthyridine-3-carbonitrile (300 mg, 1.1 mmol, 1 eq) was reacted with 2-morpholin-4-yl-1-ethylamine (3 mL, 20 eq). The crude product was purified via preparative HPLC to obtain 67 mg product (18% yield):

Workup

  1. customThe crude product was purified via preparative HPLC

Sources & evidence

ORD record
ord-494a7ca19b734ed1b60570023d55b1d3
Source dataset
uspto-grants-2008_10
Patent number
US07432279B2

Reaction notes

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