HCID 59811138, compound → HCID 58628203, compound

HRID 2113617Notes

Reaction equation

HRID 2113617 reaction equation
Cl[C:2]1(O)[C:11]2[C:6](=[CH:7][C:8]([C:12]3[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][N:13]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][NH:3]1.[C:23]([C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][C:28]=1[O:34][CH2:35][CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])([CH3:26])([CH3:25])[CH3:24]>C(#N)C>[C:23]([C:27]1[CH:32]=[CH:31][C:30]([NH:33][C:2]2[C:11]3[C:6](=[CH:7][C:8]([C:12]4[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][N:13]=4)=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:29][C:28]=1[O:34][CH2:35][CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:39])[CH3:40])([CH3:26])([CH3:24])[CH3:25]

Participants

4

Reactant 2

HCID 59811138HCID 59811138, compoundHCID 178516696HCID 178516696, compound

Product 1

HCID 58628203HCID 58628203, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Stir 4-chloro-7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ol (1.85 g, 6 mmol) and 4-tert-butyl-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenylamine (1.94 g, 6 mmol) in acetonitrile (100 mL) at 80° C. for 4 hours. Cool the mixture and collect the precipitate. Partition the residue between ethyl acetate and sodium bicarbonate solution and extract with further ethyl acetate. Dry the combined extracts (MgSO4) and concentrate under reduced pressure to give the title compound.

Workup

  1. temperatureCool the mixture
  2. customcollect the precipitate
  3. customPartition the residue between ethyl acetate and sodium bicarbonate solution
  4. extractionextract with further ethyl acetate
  5. dry with materialDry the combined extracts (MgSO4)
  6. concentrationconcentrate under reduced pressure

Sources & evidence

ORD record
ord-ce0ae19659e4415aa4f6b847bbfad64b
Source dataset
uspto-grants-2008_10
Patent number
US07432275B2

Reaction notes

Loading…