HCID 58628194, compound → HCID 58628205, compound

HRID 2113621Notes

Reaction equation

HRID 2113621 reaction equation
C([O:8][P:9](=[O:53])([O:45]CC1C=CC=CC=1)[O:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[C:18]([NH:20][C:21]2[C:30]3[C:25](=[CH:26][C:27]([C:31]4[C:36]([C:37]([F:40])([F:39])[F:38])=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:28][CH:29]=3)[N:24]=[CH:23][N:22]=2)[CH:17]=[CH:16][C:15]=1[C:41]([CH3:44])([CH3:43])[CH3:42])C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:41]([C:15]1[CH:16]=[CH:17][C:18]([NH:20][C:21]2[C:30]3[C:25](=[CH:26][C:27]([C:31]4[C:36]([C:37]([F:40])([F:39])[F:38])=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:28][CH:29]=3)[N:24]=[CH:23][N:22]=2)=[CH:19][C:14]=1[O:13][CH2:12][CH2:11][O:10][P:9](=[O:8])([OH:53])[OH:45])([CH3:44])([CH3:42])[CH3:43]

Participants

5

Reactant 2

HCID 58628194HCID 58628194, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58628205HCID 58628205, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Hydrogenate a mixture of phosphoric acid 2-{2-tert-butyl-5-[7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ylamino]-phenoxy}-ethyl ester dibenzyl ester (65 mg) and 10% Pd/C (60 mg) in methanol under 1 atmosphere of hydrogen for 12 hours. Filter the mixture through Celite and evaporate to dryness to give the title compound. MS 563 (M+1).

Workup

  1. filtrationFilter the mixture through Celite
  2. customevaporate to dryness

Sources & evidence

ORD record
ord-b272360b1137475ba1896ce164a2f405
Source dataset
uspto-grants-2008_10
Patent number
US07432275B2

Reaction notes

Loading…