HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58628194, compound → HCID 58628205, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58628194 | HCID 58628194 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58628205 | HCID 58628205 | — |
Reaction Steps
Hydrogenate a mixture of phosphoric acid 2-{2-tert-butyl-5-[7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ylamino]-phenoxy}-ethyl ester dibenzyl ester (65 mg) and 10% Pd/C (60 mg) in methanol under 1 atmosphere of hydrogen for 12 hours. Filter the mixture through Celite and evaporate to dryness to give the title compound. MS 563 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432275B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-b272360b1137475ba1896ce164a2f405 |
| Source note | uspto-grants-2008_10 |