1,1,1-Trifluoro-2-iodoethane → Diphenyl(2,2,2-trifluoroethyl)phosphine oxide

HRID 2113638Notes

Reaction equation

HRID 2113638 reaction equation
[C:1]1([PH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([O-:11])OCC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:18][C:19]([F:23])([F:22])[CH2:20]I>>[F:18][C:19]([F:23])([F:22])[CH2:20][P:7](=[O:11])([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 178476780HCID 178476780, compound

Product 1

HCID 11323568Diphenyl(2,2,2-trifluoroethyl)phosphine oxide

Procedure

A mixture of ethyl diphenylphosphonite (1.98 g; 5.8 mmol) and 2,2,2-trifluoroethyl iodide (6.1 g; 29 mmol) was stirred at room temperature under nitrogen for 24 hrs. The excess reagents were removed under vacuum. The residue was purified on silica gel using a 0-100% hexane-ethyl acetate gradient to give the target as a white powder (800 mg; 49%).

Workup

  1. customThe excess reagents were removed under vacuum
  2. customThe residue was purified on silica gel using a 0-100% hexane-ethyl acetate gradient
  3. customto give the target as a white powder (800 mg; 49%)

Sources & evidence

ORD record
ord-1570d135208549a2ae174176802a2641
Source dataset
uspto-grants-2008_10
Patent number
US07432281B2

Reaction notes

Loading…