1,1,1-Trifluoro-2-iodoethane → Diphenyl(2,2,2-trifluoroethyl)phosphine oxide

Participants

Reaction Steps

A mixture of ethyl diphenylphosphonite (1.98 g; 5.8 mmol) and 2,2,2-trifluoroethyl iodide (6.1 g; 29 mmol) was stirred at room temperature under nitrogen for 24 hrs. The excess reagents were removed under vacuum. The residue was purified on silica gel using a 0-100% hexane-ethyl acetate gradient to give the target as a white powder (800 mg; 49%).

Provenance & Evidence