2-Methoxyethylamine → 3-Chloro-1-(2-methoxyethyl)-4-phenyl-1H-pyrrole-2,5-dione

HRID 2113740Notes

Reaction equation

HRID 2113740 reaction equation
[Cl:1][C:2]1[C:3](=[O:14])O[C:5](=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:15][O:16][CH2:17][CH2:18][NH2:19]>C(O)(=O)C>[Cl:1][C:2]1[C:3](=[O:14])[N:19]([CH2:18][CH2:17][O:16][CH3:15])[C:5](=[O:13])[C:6]=1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 234471953-Chloro-4-phenylfuran-2,5-dione

Product 1

HCID 691442823-Chloro-1-(2-methoxyethyl)-4-phenyl-1H-pyrrole-2,5-dione

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3-chloro-4-phenylfuran-2,5-dione (0.20 mmol, 42 mg) and 2-methoxyethylamine (0.20 mmol, 15 mg) in glacial acetic acid (1 mL) was heated in a microwave reactor at 120° C. for two min. After cooling, the solvent was evaporated at reduced pressure. The crude product was used without purification.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated at reduced pressure
  3. customThe crude product was used without purification

Sources & evidence

ORD record
ord-1a1a1dcb5d09461c8251235b5e1dd202
Source dataset
uspto-grants-2008_10
Patent number
US07432288B2

Reaction notes

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