反应详情

温度

150 °C

3-Chloro-1-(2-methoxyethyl)-4-phenyl-1H-pyrrole-2,5-dione (0.13 mmol, 36 mg) and 4-difluoromethoxyaniline (0.28 mmol, 45 mg) were dissolved in DMF (1 mL). The mixture was heated in a microwave reactor at 150° C. for 20 min. After cooling, the reaction mixture was purified by HPLC (95% 0.1M ammonium acetate buffer: 5% CH3CN→100% CH3CN) to give 13 mg (24%) of the title compound. 1H NMR (400 MHz, CDCl3): δ 7.25 (bs, 1H), 7.19-7.08 (m, 3H), 7.02-6.97 (m, 2H), 6.81-6.75 (m, 2H), 6.66-6.60 (m, 2H), 6.36 (t, J=74.0 Hz, 1H), 3.83 (t, J=5.7 Hz, 2H), 3.63 (t, J=5.7 Hz, 2H), 3.38 (s, 3H)

1. temperatureAfter cooling
2. customthe reaction mixture was purified by HPLC (95% 0.1M ammonium acetate buffer: 5% CH3CN→100% CH3CN)