反应详情

7-(2-Chloro-4,6-dimethylphenyl)-2-methyl-3-(1-propylbut-1-enyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine (3-1; 41.5 mg) was dissolved in acetic acid (1 mL) and 12 mg of 10% palladium on carbon was added. The mixture was stirred under hydrogen at one atmosphere for 12 h. The mixture was diluted with ethyl acetate and filtered through diatomaceous earth and the residue was washed with ethyl acetate. The ethyl acetate filtrate was washed with aqueous sodium bicarbonate, dried with magnesium sulfate, and concentrated. The residue was chromatographed on silica gel eluting with an acetone/hexane gradient to provide 10.2 mg of 4-1 as a crystalline film: ms (MH+)=374.

1. filtrationfiltered through diatomaceous earth
2. washthe residue was washed with ethyl acetate
3. washThe ethyl acetate filtrate was washed with aqueous sodium bicarbonate
4. dry with materialdried with magnesium sulfate
5. concentrationconcentrated
6. customThe residue was chromatographed on silica gel eluting with an acetone/hexane gradient