2-Aminothiazole → HCID 23093046, compound

HRID 2113850Notes

Reaction equation

HRID 2113850 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH2:26][CH3:27])(=[O:25])=[O:24])=[N:21][CH:22]=1.[O:28]([CH2:36][C@H:37]([OH:39])[CH3:38])[Si](C(C)(C)C)(C)C.[NH2:40][C:41]1[S:42][CH:43]=[CH:44][N:45]=1>>[CH2:26]([S:23]([C:20]1[N:21]=[CH:22][C:17]([O:10][C:8]2[CH:9]=[C:4]([CH:5]=[C:6]([O:39][CH:37]([CH3:38])[CH2:36][OH:28])[CH:7]=2)[C:3]([NH:40][C:41]2[S:42][CH:43]=[CH:44][N:45]=2)=[O:15])=[CH:18][CH:19]=1)(=[O:25])=[O:24])[CH3:27]

Participants

5

Reactant 4

HCID 21552-AminothiazoleHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 225031645-Bromo-2-(ethylsulfonyl)pyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093046HCID 23093046, compound

Procedure

The compound of Production Example 151 was obtained as a colorless amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-ethanesulfonylpyridine, (2R)-1-(tert-butyldimethylsiloxy)-2-hydroxypropane and 2-aminothiazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 151 was obtained as a colorless amorphous substance

Sources & evidence

ORD record
ord-a17057c7dd7e44b08539d24ac3f1d05a
Source dataset
uspto-grants-2008_10
Patent number
US07432287B2

Reaction notes

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