1,3-Difluoro-2-propanol → HCID 23093082, compound

HRID 2113859Notes

Reaction equation

HRID 2113859 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Cl.Cl[C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1.[F:24][CH2:25][CH:26]([OH:29])[CH2:27][F:28].[NH2:30][C:31]1[CH:35]=[CH:34][N:33]([CH3:36])[N:32]=1>>[F:24][CH2:25][CH:26]([CH2:27][F:28])[O:29][C:6]1[CH:7]=[C:8]([O:10][C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:30][C:31]1[CH:35]=[CH:34][N:33]([CH3:36])[N:32]=1)=[O:15]

Participants

5

Reactant 4

HCID 679851,3-Difluoro-2-propanolHCID 818524-Chloropyridine hydrochlorideHCID 1372541-Methyl-3-aminopyrazoleHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093082HCID 23093082, compound

Procedure

The compound of Production Example 164 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 4-chloropyridine hydrochloride, 1,3-difluoro-2-propanol and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 164 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-f4749c5936734638a88b95f9a9ff7c3d
Source dataset
uspto-grants-2008_10
Patent number
US07432287B2

Reaction notes

Loading…