Hydroxylamine → HCID 178513323, compound

HRID 2113898Notes

Reaction equation

HRID 2113898 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH2:10][OH:11]>C(O)C>[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]([NH:10][OH:11])=[NH:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 145174-Fluorobenzonitrile

Product 1

HCID 178513323HCID 178513323, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

In a 50 ml round bottom flask, 3.0 g (24.8 mmol) of 4-fluoro-benzonitrile are suspended in 50 ml of ethanol and 1.46 ml of aqueous hydroxylamine (50%, 24.8 mmol) are added. The mixture is heated to 90° C. and the resulting solution stirred at this temperature for 16 h. After cooling to room temperature, the solvent is removed in vacuo and the resulting residue recrystallised from 25 ml of ethanol/water (1:5) which yields a white solid. Mass spectrum: m/z (M+H)+: 155.0

Workup

  1. temperatureAfter cooling to room temperature
  2. customthe solvent is removed in vacuo
  3. customthe resulting residue recrystallised from 25 ml of ethanol/water (1:5) which
  4. customyields a white solid

Sources & evidence

ORD record
ord-6adbb530c5f74ec4add330a92072f8c6
Source dataset
uspto-grants-2008_10
Patent number
US07432293B2

Reaction notes

Loading…