2-Aminopyridine-4-carboxylic acid → HCID 69200846, compound

HRID 2114092Notes

Reaction equation

HRID 2114092 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[NH2:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][N:31]=1)[C:26](O)=[O:27]>>[NH2:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][N:31]=1)[C:26]([NH:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[C:5]([CH3:21])=[CH:4][CH:3]=1)=[O:27]

Participants

3

Reactant 2

HCID 2783962-Aminopyridine-4-carboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 69200846HCID 69200846, compound

Procedure

2-Amino-N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isonicotinamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and 2-aminoisonicotinic acid using method B. NMR; δH CDCl3 8.20,(1H, d), 7.93,(1H, s), 7.82,(2H, d), 7.60,(1H, d), 7.46,(1H, s), 7.39,(2H,d), 7.30-7.26,(2H, m), 6.96,(1H, s), 6.29,(1H, b), 4.67,(2H, s), 3.34,(2H, m), 2.24,(3H, s), 1.08,(1H, m), 0.59,(2H, m), 0.30,(2H, m). LCMS: retention time 2.75 min, MH+401.

Sources & evidence

ORD record
ord-802f74ea128c4f7a948883e33b09bf85
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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