4-Methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylic acid → HCID 69204663, compound

HRID 2114119Notes

Reaction equation

HRID 2114119 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[CH3:22][C:23]1[N:24]=[C:25]([C:31]2[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=2)[S:26][C:27]=1[C:28](O)=[O:29]>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:28]([C:27]4[S:26][C:25]([C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)=[N:24][C:23]=4[CH3:22])=[O:29])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 27634894-Methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 69204663HCID 69204663, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-4-methyl-2-(pyrid-3-yl)thiazole-5- carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and 4-methyl-2-(pyrid-3-yl)thiazole-5-carboxylic acid using method D. NMR; δH CDCl3 9.18,(1H, b), 8.72,(1H, b), 8.27,(1H, d), 7.84,(2H, d), 7.59,(1H, s), 7.55,(1H, dd), 7.45-7.40,(4H, m), 7.30,(1H, d), 6.27,(1H, t), 3.36,(2H, m), 2.83,(3H, s), 2.25,(3H, s), 1.09,(1H, m), 0.58,(2H, m), 0.30,(2H, m). LCMS: retention time 3.41 min, MH+483.

Sources & evidence

ORD record
ord-3c4ee76cc46a4d4abebb51a6366e67e3
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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