4-Methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylic acid → HCID 69204663, compound

Participants

Reaction Steps

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-4-methyl-2-(pyrid-3-yl)thiazole-5- carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and 4-methyl-2-(pyrid-3-yl)thiazole-5-carboxylic acid using method D. NMR; δH CDCl3 9.18,(1H, b), 8.72,(1H, b), 8.27,(1H, d), 7.84,(2H, d), 7.59,(1H, s), 7.55,(1H, dd), 7.45-7.40,(4H, m), 7.30,(1H, d), 6.27,(1H, t), 3.36,(2H, m), 2.83,(3H, s), 2.25,(3H, s), 1.09,(1H, m), 0.58,(2H, m), 0.30,(2H, m). LCMS: retention time 3.41 min, MH+483.

Provenance & Evidence