HCID 2745164, compound → HCID 69203229, compound

HRID 2114120Notes

Reaction equation

HRID 2114120 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[CH2:22]([N:24]1[C:28]([C:29](O)=[O:30])=[CH:27][C:26]([C:32]2[S:33][CH:34]=[CH:35][CH:36]=2)=[N:25]1)[CH3:23]>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:29]([C:28]4[N:24]([CH2:22][CH3:23])[N:25]=[C:26]([C:32]5[S:33][CH:34]=[CH:35][CH:36]=5)[CH:27]=4)=[O:30])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 2745164HCID 2745164, compoundHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 69203229HCID 69203229, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-1-ethyl-3-(thiophen-2-yl)pyrazole-5- carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and 1-ethyl-3-(thiophen-2-yl)pyrazole-5- carboxylic acid using method D. NMR; δH CDCl3 8.02,(1H, b), 7.86-7.83,(3H, m), 7.57,(1H, dd), 7.47,(1H, d), 7.40,(2H, d), 7.34,(1H, m), 7.30-7.26,(3H, m), 7.07,(1H, m), 4.63,(2H, q), 3.35,(2H, m), 2.24,(3H, s), 1.08,(1H, m), 0.58,(2H, m), 0.30,(2H, m). LCMS: retention time 3.81 min, MH+485.

Sources & evidence

ORD record
ord-a68fc4e5b9ec4c7ab6fcc19890ee6148
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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