Cyclopropanecarboxylic acid → HCID 44578402, compound

HRID 2114123Notes

Reaction equation

HRID 2114123 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[CH:22]1([C:25](O)=[O:26])[CH2:24][CH2:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:25]([CH:22]4[CH2:24][CH2:23]4)=[O:26])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 44578402HCID 44578402, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)cyclopropanecarboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and cyclopropanecarboxylic acid using method D. NMR; δH [2H6]—DMSO 10.18,(1H, s), 8.60,(1H, t), 7.91,(2H, d), 7.50-7.47,(2H, m), 7.40,(2H, d), 7.21,(1H, d), 3.16,(2H, t), 2.16,(3H, s), 1.74,(1H, m),1.04,(1H, m), 0.77-0.75,(4H, m), 0.43,(2H, m), 0.23,(2H, m). LCMS: retention time 3.19 min, MH+349.

Sources & evidence

ORD record
ord-aa2926c0c1e948f99d8fc0dc999656df
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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