Thiophene-3-carboxylic acid → HCID 44578460, compound

HRID 2114125Notes

Reaction equation

HRID 2114125 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[S:22]1[CH:26]=[CH:25][C:24]([C:27](O)=[O:28])=[CH:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:27]([C:24]4[CH:25]=[CH:26][S:22][CH:23]=4)=[O:28])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 6918Thiophene-3-carboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 44578460HCID 44578460, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)thiophene-3-carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4- carboxamide and 3-thiophene carboxylic acid using method D. NMR; δH [2H6]—DMSO 10.05,(1H, s), 8.62,(1H, t), 8.32,(1H, m), 7.93,(2H, d), 7.69,(1H, dd), 7.65-7.61,(3H, m), 7.44,(2H, d), 7.28,(1H, d), 3.16,(2H, t), 2.20,(3H, s), 1.04,(1H, m), 0.44,(2H, m), 0.24,(2H, m). LCMS: retention time 3.41 min, MH+391.

Sources & evidence

ORD record
ord-4c79301122374185b3cd2c6639713163
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

Loading…