Oxane-4-carboxylic acid → HCID 69204378, compound

HRID 2114127Notes

Reaction equation

HRID 2114127 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[O:22]1[CH2:27][CH2:26][CH:25]([C:28](O)=[O:29])[CH2:24][CH2:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:28]([CH:25]4[CH2:26][CH2:27][O:22][CH2:23][CH2:24]4)=[O:29])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 219302Oxane-4-carboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 69204378HCID 69204378, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)tetrahydropyran-4- carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4- carboxamide and tetrahydropyran-4-carboxylic acid using method D. NMR; δH [2H6]—DMSO 9.89,(1H, s), 8.61,(1H, t), 7.91,(2H, d), 7.52-7.48,(2H, m), 7.40,(2H, d), 7.21,(1H, d), 3.89,(2H, m), 3.37,(1H, m), 3.16,(2H, t), 2.56,(2H, m), 2.16,(3H, s), 1.65,(3H, m), 1.04,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 2.94 min, MH+393.

Sources & evidence

ORD record
ord-d317b88f32ba417581d98884f001ca56
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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