Oxane-4-carboxylic acid → HCID 69204378, compound

Participants

Reaction Steps

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)tetrahydropyran-4- carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4- carboxamide and tetrahydropyran-4-carboxylic acid using method D. NMR; δH [2H6]—DMSO 9.89,(1H, s), 8.61,(1H, t), 7.91,(2H, d), 7.52-7.48,(2H, m), 7.40,(2H, d), 7.21,(1H, d), 3.89,(2H, m), 3.37,(1H, m), 3.16,(2H, t), 2.56,(2H, m), 2.16,(3H, s), 1.65,(3H, m), 1.04,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 2.94 min, MH+393.

Provenance & Evidence