Hydrogen chloride-ethyl acetate → HCID 86035991, compound

HRID 2114165Notes

Reaction equation

HRID 2114165 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([O:15][C:16]1[C:17]([F:34])=[C:18]([C:31]([OH:33])=[O:32])[C:19]([NH:23]C(OC(C)(C)C)=O)=[CH:20][C:21]=1[F:22])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[ClH:1].[NH2:23][C:19]1[C:18]([C:31]([OH:33])=[O:32])=[C:17]([F:34])[C:16]([O:15][CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[C:21]([F:22])[CH:20]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 23130265HCID 23130265, compound

Product 1

HCID 86035991HCID 86035991, compound

Conditions

Temperature
60 °C

Procedure

4N Hydrochloric acid-ethyl acetate (35 mL) was added to 3-benzyloxy-6-tert-butoxycarbonylamino-2,4-difluorobenzenecarboxylic acid (3.53 g), and the mixture was stirred at 60° C. for 1 hour. The reaction mixture was cooled down to room temperature, and the resultant precipitated solid was collected by filtration and dried to give 6-amino-3-benzyloxy-2,4-difluorobenzenecarboxylic acid hydrochloride (2.08 g).

Workup

  1. temperatureThe reaction mixture was cooled down to room temperature
  2. customthe resultant precipitated solid
  3. filtrationwas collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-0e64663fb09e42368f35b95001878e0f
Source dataset
uspto-grants-2008_10
Patent number
US07432392B2

Reaction notes

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