Hydrogen chloride-ethyl acetate → HCID 86035991, compound

Participants

Reaction Conditions

Reaction Steps

4N Hydrochloric acid-ethyl acetate (35 mL) was added to 3-benzyloxy-6-tert-butoxycarbonylamino-2,4-difluorobenzenecarboxylic acid (3.53 g), and the mixture was stirred at 60° C. for 1 hour. The reaction mixture was cooled down to room temperature, and the resultant precipitated solid was collected by filtration and dried to give 6-amino-3-benzyloxy-2,4-difluorobenzenecarboxylic acid hydrochloride (2.08 g).

Provenance & Evidence