HCID 57503457, compound → HCID 23641307, compound

HRID 2114167Notes

Reaction equation

HRID 2114167 reaction equation
[CH2:1]([O:3][C:4](=[O:55])[C:5]([CH2:17][O:18][C:19](=[O:54])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([C:30]2[C:31]([C:36]3[CH:41]=[CH:40][C:39]([C:42]([F:45])([F:44])[F:43])=[CH:38][CH:37]=3)=[CH:32][CH:33]=[CH:34][CH:35]=2)=[O:29])=[C:23]([O:46]CC2C=CC=CC=2)[CH:22]=1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]>CO.[C].[Pd]>[CH2:9]([O:8][C:6](=[O:7])[C:5]([CH2:17][O:18][C:19](=[O:54])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([C:30]2[C:31]([C:36]3[CH:37]=[CH:38][C:39]([C:42]([F:43])([F:45])[F:44])=[CH:40][CH:41]=3)=[CH:32][CH:33]=[CH:34][CH:35]=2)=[O:29])=[C:23]([OH:46])[CH:22]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]([O:3][CH2:1][CH3:2])=[O:55])[CH3:10]

Participants

4

Reactant 1

HCID 57503457HCID 57503457, compound

Product 1

HCID 23641307HCID 23641307, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

2-(2-{3-Benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)amino]phenyl}acetoxymethyl)-2-phenylmalonic acid diethyl ester (Reference Example 2-4) (0.310 g) was dissolved in methanol, and palladium carbon (0.04 g) was added thereto. The mixture was hydrogenated at normal pressure for 2 hours. The reaction solution was filtered through a Celite, and the filtrate was concentrated to give the title compound as a colorless non-crystalline substance (0.245 g).

Workup

  1. filtrationThe reaction solution was filtered through a Celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-3506c636bafc4683bd63d16f181d20a1
Source dataset
uspto-grants-2008_10
Patent number
US07432392B2

Reaction notes

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