Ethyl 3-acetamido-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate → 3-Amino-3,4-dihydroquinolin-2(1H)-one

HRID 2114284Notes

Reaction equation

HRID 2114284 reaction equation
C(OC([C:6]1([NH:17]C(=O)C)[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:16])=O)C>Cl>[NH2:17][CH:6]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:16]

Participants

3

Reactant 1

HCID 21853904Ethyl 3-acetamido-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate

Product 1

HCID 134994273-Amino-3,4-dihydroquinolin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 81 in 6 M HCl was refluxed for a time sufficient for reaction completion. After cooling to rt, the mixture was rotary evaporated and dried under vacuum to give 82 as its hydrochloride salt.

Workup

  1. temperaturewas refluxed for a time sufficient for reaction completion
  2. customthe mixture was rotary evaporated
  3. customdried under vacuum

Sources & evidence

ORD record
ord-8311a831c3ed4fc699effc91d0270419
Source dataset
uspto-grants-2008_10
Patent number
US07432379B2

Reaction notes

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