Pyrazole → HCID 178456038, compound

HRID 2114301Notes

Reaction equation

HRID 2114301 reaction equation
N1C=[CH:4][CH:3]=N1.[N:6]1([CH:11](C)[CH2:12][NH:13][C:14]([C:16]2[C:20]([Br:21])=[C:19]([NH:22][C:23](=[O:31])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])[NH:18][N:17]=2)=[O:15])[CH2:10]CC[CH2:7]1>>[CH3:10][N:6]([CH2:11][C@H:12]([NH:13][C:14]([C:16]1[C:20]([Br:21])=[C:19]([NH:22][C:23](=[O:31])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])[NH:18][N:17]=1)=[O:15])[CH2:3][CH3:4])[CH3:7]

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 178457755HCID 178457755, compound

Product 1

HCID 178456038HCID 178456038, compound

Procedure

The pyrazole acid, prepared as described in Procedure 8, was coupled with (R)—N,N-dimethyl-1,2-butanediamine (prepared as shown in Procedure 2) using the method of Procedure 3.

Sources & evidence

ORD record
ord-195bf50178f44630ac2a6a2a80649330
Source dataset
uspto-grants-2008_10
Patent number
US07432379B2

Reaction notes

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