Pyrazole → HCID 178464024, compound

HRID 2114302Notes

Reaction equation

N1C=C[CH:3]=N1.[N:6]1([CH:11](C)[CH2:12][NH:13][C:14]([C:16]2[C:20]([Br:21])=[C:19]([NH:22][C:23](=[O:31])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])[NH:18][N:17]=2)=[O:15])[CH2:10][CH2:9][CH2:8][CH2:7]1>>[CH2:10]([N:6]([CH2:7][CH3:8])[CH2:11][C@H:12]([NH:13][C:14]([C:16]1[C:20]([Br:21])=[C:19]([NH:22][C:23](=[O:31])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])[NH:18][N:17]=1)=[O:15])[CH3:3])[CH3:9]

Participants

Reactant 2

HCID 1048Pyrazole

HCID 178457755HCID 178457755, compound

Product 1

HCID 178464024HCID 178464024, compound

Procedure

The pyrazole acid, prepared as described in Procedure 8, was coupled with (R)—N,N-diethyl-1,2-propanediamine (prepared as shown in Procedure 2) using the method of Procedure 3.

Sources & evidence

ORD record: ord-903b0868fc59406dbd74bd7315eaa51d
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07432379B2

Reaction notes

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