HRID2114305

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1048

Pyrazole

C3H4N2

HCID22027821

1-(4-Pyridinyl)-4-piperidineethanamine

C12H19N3

HCID22320258

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn(-c2ccncc2)c1NC(=O)c1ccccc1Cl

HCID59773339

未命名化合物

PROCEDURE

实验过程

The pyrazole acid, prepared as described in Procedure 8 using 5-Amino-4-methyl-1-pyridin-4-yl-1H-pyrazole-3-carboxylic acid ethyl ester (prepared as described in Procedure 41 using 3-cyano-3-methyl-2-oxopropanoic acid ethyl ester (U.S. Pat. No. 4,6526,69) and 4-hydrazinopyridine hydrochloride (Apin Chemical, 25637 h)) in place of compound 20, was coupled to 2-(3,4,5,6-tetrahydro-2H-[1,4′]bipyridin-4-yl)ethylamine (prepared as described in Procedure 14) using the method of Procedure 10.

WORKUP

后处理

customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd20270f0689464081b099627f76c76b
来源数据集: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07432379B2
来源说明: uspto-grants-2008_10

反应 SMILES

N1[CH:5]=[CH:4][CH:3]=N1.C(O[C:9]([C:11]1[C:15]([CH3:16])=[C:14]([NH2:17])[N:13]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[N:12]=1)=[O:10])C.C(OC(=O)[C:28](=[O:33])[CH:29]([C:31]#N)[CH3:30])C.[ClH:35].N(C1C=CN=CC=1)N.NC1N(C(OC(C)(C)C)=O)N=C(C(OC)=O)C=1.[N:61]1([C:70]2[CH:75]=[CH:74][N:73]=[CH:72][CH:71]=2)[CH2:66][CH2:65][CH:64]([CH2:67][CH2:68][NH2:69])[CH2:63][CH2:62]1>>[N:61]1([C:70]2[CH:75]=[CH:74][N:73]=[CH:72][CH:71]=2)[CH2:66][CH2:65][CH:64]([CH2:67][CH2:68][NH:69][C:9]([C:11]2[C:15]([CH3:16])=[C:14]([NH:17][C:28](=[O:33])[C:29]3[CH:31]=[CH:5][CH:4]=[CH:3][C:30]=3[Cl:35])[N:13]([C:18]3[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=3)[N:12]=2)=[O:10])[CH2:63][CH2:62]1