HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 4-Bromo-5-(2-chloro-benzoylamino)-1-methyl-pyrazole-3-carboxylic acid [2-(4-(pyridin-4-yl)-piperazin-1-yl)ethyl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 2-Chlorobenzoyl chloride | HCID 69110 | — |
| Reactant | 2-[4-(4-Pyridinyl)piperazino]ethylamine | HCID 18440675 | — |
| Reactant | HCID 178461679 | HCID 178461679 | — |
| Product | 4-Bromo-5-(2-chloro-benzoylamino)-1-methyl-pyrazole-3-carboxylic acid [2-(4-(pyridin-4-yl)-piperazin-1-yl)ethyl]amide | HCID 59773338 | — |
Reaction Steps
The pyrazole acid, prepared by coupling methyl ester 85 (Gen. Proc. 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Gen. Proc. 8. was coupled to 2-(4-pyridin-4-yl-piperazin-1-yl)ethylamine (CA 985683) using the method of Procedure 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432379B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-ddcc84bfbb784245bf475f8be3e372d8 |
| Source note | uspto-grants-2008_10 |