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HRID2114310

反应详情

EQUATION

反应方程式

HRID 2114310 的结构方程式

REACTANTS

反应物

4
结构：c1cn[nH]c1
HCID1048

Pyrazole

C3H4N2

结构：O=C(Cl)c1ccccc1Cl
HCID69110

Benzoyl chloride, 2-chloro-

C7H4Cl2O

结构：NCCN1CCN(c2ccncc2)CC1
HCID18440675

未命名化合物

结构：C[C@H](c1ccccc1)N(C)C(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br
HCID178461679

未命名化合物

PRODUCTS

生成物

1
结构：Cn1nc(C(=O)NCCN2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl
HCID59773338

未命名化合物

PROCEDURE

实验过程

The pyrazole acid, prepared by coupling methyl ester 85 (Gen. Proc. 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Gen. Proc. 8. was coupled to 2-(4-pyridin-4-yl-piperazin-1-yl)ethylamine (CA 985683) using the method of Procedure 10.

WORKUP

后处理

  1. customfollowed by hydrolysis and bromination