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HRID2114311

反应详情

EQUATION

反应方程式

HRID 2114311 的结构方程式

REACTANTS

反应物

6
结构：c1cn[nH]c1
HCID1048

Pyrazole

C3H4N2

结构：NN1CCCCC1
HCID16658

N-Aminopiperidine

C5H12N2

结构：O=C(Cl)c1ccccc1Cl
HCID69110

Benzoyl chloride, 2-chloro-

C7H4Cl2O

结构：CC(C)(C)OC(=O)N[C@H](CCCCN)C(=O)O
HCID7018770

N2-[(1,1-Dimethylethoxy)carbonyl]-D-lysine

C11H22N2O4

结构：CC(C)(C)OC(=O)N[C@@H]1CCCCN(C(=O)OCc2ccccc2)C1
HCID69152935

未命名化合物

结构：C[C@H](c1ccccc1)N(C)C(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br
HCID178461679

未命名化合物

PRODUCTS

生成物

1
结构：Cn1nc(C(=O)N[C@@H]2CCCCNC2)c(Br)c1NC(=O)c1ccccc1Cl
HCID59773409

未命名化合物

PROCEDURE

实验过程

The pyrazole acid, prepared by coupling methyl ester 85 (Procedure 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Procedure 8, was coupled to (R)-3-tert-butoxycarbonylaminoazepane-1-carboxylic acid benzyl ester (prepared as described in Procedure 23 using Boc-D-Lys-OH (Bachem, A-2705) followed by Cbz protection of the piperidine amine using the method of Procedure 30) using Procedure 3. Removal of the Cbz group using the method of Procedure 20 afforded the title compound.

WORKUP

后处理

  1. customfollowed by hydrolysis and bromination
  2. customprepared
  3. customRemoval of the Cbz group