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HRID2114312

反应详情

EQUATION

反应方程式

HRID 2114312 的结构方程式

REACTANTS

反应物

4
结构：c1cn[nH]c1
HCID1048

Pyrazole

C3H4N2

结构：O=C(Cl)c1ccccc1Cl
HCID69110

Benzoyl chloride, 2-chloro-

C7H4Cl2O

结构：N#Cc1ccc(CCN)cc1
HCID21912525

4-(2-Aminoethyl)benzonitrile

C9H10N2

结构：C[C@H](c1ccccc1)N(C)C(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br
HCID178461679

未命名化合物

PRODUCTS

生成物

2
结构：NCCN
HCID3301

Ethylenediamine

C2H8N2

结构：CN1CCC(CCNC(=O)c2nn(C)c(NC(=O)c3ccccc3Cl)c2Br)CC1
HCID59773502

未命名化合物

PROCEDURE

实验过程

The pyrazole acid, prepared by coupling methyl ester 85 (Procedure 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Procedure 8, was coupled to amine 169 (Procedure 34) using the method of Procedure 10. Formation of the amidine using the method of Procedure 33 using ethylene diamine afforded the title compound.

WORKUP

后处理

  1. customfollowed by hydrolysis and bromination