1-([1,1'-Biphenyl]-4-yl)-N-methyl-2-(pyrrolidin-1-yl)ethan-1-amine → HCID 46847713, compound

HRID 2114332Notes

Reaction equation

HRID 2114332 reaction equation
ClC1C=C(N(C)CC(O)=O)C=CC=1Cl.[Br:15][C:16]1[C:17]([Br:31])=[CH:18][C:19]2[O:24][CH2:23][C:22](=[O:25])[N:21]([CH2:26][C:27]([OH:29])=O)[C:20]=2[CH:30]=1.C1(C2C=CC=CC=2)C=CC(C(NC)CN2CCCC2)=CC=1.[C:53]1([C:69]2[CH:74]=[CH:73][CH:72]=[CH:71][CH:70]=2)[CH:58]=[CH:57][C:56]([CH:59]([NH:67][CH3:68])[CH2:60][N:61]2[CH2:66][CH2:65][O:64][CH2:63][CH2:62]2)=[CH:55][CH:54]=1>>[C:53]1([C:69]2[CH:74]=[CH:73][CH:72]=[CH:71][CH:70]=2)[CH:54]=[CH:55][C:56]([CH:59]([N:67]([CH3:68])[C:27](=[O:29])[CH2:26][N:21]2[C:20]3[CH:30]=[C:16]([Br:15])[C:17]([Br:31])=[CH:18][C:19]=3[O:24][CH2:23][C:22]2=[O:25])[CH2:60][N:61]2[CH2:62][CH2:63][O:64][CH2:65][CH2:66]2)=[CH:57][CH:58]=1

Participants

5

Reactant 4

HCID 27567161-([1,1'-Biphenyl]-4-yl)-N-methyl-2-(pyrrolidin-1-yl)ethan-1-amineHCID 57418650HCID 57418650, compoundHCID 57425536[1-(4-Biphenylyl)-2-(4-morpholinyl)ethyl]methylamineHCID 57457147HCID 57457147, compound

Product 1

HCID 46847713HCID 46847713, compoundYield 58%

Procedure

The title compound was prepared according to the procedure described in example 11 replacing N-(3,4-dichlorophenyl)-N-methylglycine with (6,7-dibromo-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid, and [1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]methylamine with the product from step b) above to give the title compound (52 mg, 58%). MS (ES) m/e 643 [M+H]+

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-92a802837be845e9aaf935a82d69dd5f
Source dataset
uspto-grants-2008_10
Patent number
US07432258B2

Reaction notes

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