2-Bromophenol → HCID 59809540, compound

HRID 2114497Notes

Reaction equation

HRID 2114497 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:13][CH2:12]2)=[C:6]([OH:24])[CH:5]=1.BrC1C=CC=CC=1O.F[C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([O:41][CH3:42])[C:36]=1[N+]([O-])=O.FC1C=C(C=CC=1[N+]([O-])=O)C#N>>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[CH:8][C:7]2[N:10]([CH:11]3[CH2:12][CH2:13][N:14]([CH2:17][C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:15][CH2:16]3)[C:39]3[C:38]([O:24][C:6]=2[CH:5]=1)=[C:37]([O:41][CH3:42])[CH:36]=[CH:35][CH:40]=3)=[O:25]

Participants

5

Reactant 4

HCID 72442-BromophenolHCID 27827761-Fluoro-3-methoxy-2-nitrobenzeneHCID 27833993-Fluoro-4-nitrobenzonitrileHCID 59809567HCID 59809567, compound

Product 1

HCID 59809540HCID 59809540, compound

Procedure

Using an adaptation of the method described in Procedure 1, substituting 4-(1-benzyl-piperidin-4-ylamino)-3-hydroxy-benzoic acid methyl ester, 1d for 2-bromophenol, and 1-fluoro-3-methoxy-2-nitrobenzene for 3-fluoro-4-nitrobenzonitrile, the title compound 10-(1-benzyl-piperidin-4-yl)-6-methoxy-10H-phenoxazine-3-carboxylic acid methyl ester, 2d was obtained.

Sources & evidence

ORD record
ord-b62c524420904c8caad1d11a6e6fed6b
Source dataset
uspto-grants-2008_10
Patent number
US07432257B2

Reaction notes

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