HRID2114511

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734378

3-Pyridinylboronic acid

C5H6BNO2

HCID2734379

Pyridine-4-boronic acid

C5H6BNO2

HCID11516034

未命名化合物

2 次

HCID59809550

未命名化合物

PRODUCTS

产物

HCID59809559

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418397

未命名化合物

溶剂HCID962

Water

H2O

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Using an adaptation of the method described in Procedure 16, substituting 4-(3-chloro-phenoxazin-10-yl)-piperidine-1-carboxylic acid tert-butyl ester, 2i, for 3-bromo-10-piperidin-4-yl-10H-phenothiazine, 5e, 4-pyridyl boronic acid for 3-pyridyl boronic acid, Cp2Fe(PtBu2)2PdCl2 for Pd(PPh3)4 and a 5:1 mixture of dioxane:water for NMP, the title compound 4-(3-pyridin-4-yl-phenoxazin-10-yl)-piperidine-1-carboxylic acid tert-butyl ester, 1k was obtained. MS m/z (MH+) 444.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-504a47f7fa4144cd944fefcd803a4ad0
来源数据集: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07432257B2
来源说明: uspto-grants-2008_10

反应SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:27]3[CH:26]=[CH:25][C:24](Cl)=[CH:23][C:22]=3[O:21][C:20]3[C:15]2=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].BrC1C=CC2N([CH:44]3[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]3)C3C(SC=2C=1)=CC=CC=3.N1C=CC(B(O)O)=CC=1.N1C=CC=C(B(O)O)C=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CN1C(=O)CCC1.O.O1CCOCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:27]3[CH:26]=[CH:25][C:24]([C:44]4[CH:49]=[CH:48][N:47]=[CH:46][CH:45]=4)=[CH:23][C:22]=3[O:21][C:20]3[C:15]2=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]