p-Fluoronitrobenzene → HCID 23104376, compound

HRID 2114522Notes

Reaction equation

HRID 2114522 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH2:11][CH:12]([CH3:16])[CH2:13][O:14][CH3:15]>>[CH3:15][O:14][CH2:13][CH:12]([NH:11][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1)[CH3:16]

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 123458Methoxyisopropylamine

Product 1

HCID 23104376HCID 23104376, compound

Procedure

21 g (0.15 mol) of 1-fluoro-4-nitrobenzene and 42 ml of 2-amino-1-methoxypropane were introduced into a 150 ml three-necked flask. The mixture was stirred for 15 minutes and brought to the boiling point. After reaction for 2 to 3 hours, the reaction medium was poured onto ice. A yellow precipitate formed. This precipitate was filtered off, washed with water, and then successively washed with a minimum amount of ethanol, isopropyl ether, and petroleum ether. 27.8 g of expected product were isolated.

Workup

  1. customAfter reaction for 2 to 3 hours
  2. additionthe reaction medium was poured onto ice
  3. customA yellow precipitate formed
  4. filtrationThis precipitate was filtered off
  5. washwashed with water
  6. washsuccessively washed with a minimum amount of ethanol, isopropyl ether, and petroleum ether

Sources & evidence

ORD record
ord-3406f11458d044f1b9a2da3dafb3f72c
Source dataset
uspto-grants-2008_10
Patent number
US07435267B2

Reaction notes

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