Potassium Hydroxide → HCID 178462354, compound

HRID 2114580Notes

Reaction equation

HRID 2114580 reaction equation
[CH:1]1([C:6]2[C:14]3[C:9](=[N:10][C:11](S(C)(=O)=O)=[N:12][C:13]=3[NH:15][CH2:16][C@H:17]([OH:19])[CH3:18])[NH:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:24][C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=1[OH:32].[OH-].[K+]>>[CH:1]1([C:6]2[C:14]3[C:9](=[N:10][C:11]([O:32][C:26]4[CH:27]=[CH:28][C:29]([F:31])=[CH:30][C:25]=4[F:24])=[N:12][C:13]=3[NH:15][CH2:16][C@H:17]([OH:19])[CH3:18])[NH:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 1230512,4-DifluorophenolHCID 178462356HCID 178462356, compound

Product 1

HCID 178462354HCID 178462354, compound

Procedure

(R)-1-(3-Cyclopentyl-6-methylsulfonyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-propan-2-ol was treated with 2,4-difluorophenol in the presence of KOH using the procedure of step 6 of Example 4 to afford 0.56 mg of (R)-1-[3-Cyclopentyl-6-(2,4-difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino]-propan-2-ol. Mass Spec. M+H=390.

Sources & evidence

ORD record
ord-26fead1285b24c9bbc6b5c0360a33992
Source dataset
uspto-grants-2008_10
Patent number
US07435731B2

Reaction notes

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