Dichloromethane → 2-Methyl-5-piperazin-1-yl-quinoline

HRID 211464Notes

Reaction equation

HRID 211464 reaction equation
[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][c:8]([N:12]3[CH2:13][CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]3)[c:9]2[cH:10][cH:11]1.[Cl:32][CH2:33][Cl:34].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][c:8]([N:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[c:9]2[cH:10][cH:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 49851900Tert-butyl 4-(2-methylquinolin-5-yl)piperazine-1-carboxylate

Product 1

HCID 498519012-Methyl-5-piperazin-1-yl-quinoline

Sources & evidence

ORD record
ord-2942eb2b7b794264909cfff58035a244
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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