1,3-Dibromo-5-fluorobenzene → 3,5-Dibromoanisole

Sodium methoxide (8.80 ml of a 4.5M solution in methanol, 41.0 mmol) was added dropwise to a stirred solution of 3,5-dibromofluorobenzene (5.00 g, 19.0 mmol) in N,N-dimethylformamide (95 ml) at 0° C. under nitrogen. The reaction was allowed to warm to room temperature, stirred for 1 hour and then concentrated under reduced pressure. The residue was dissolved in ether and the resulting solution was washed with water (3×300 ml) and brine (300 ml), dried over magnesium sulphate, filtered and concentrated under reduced pressure to provide the title compound (5.13 g) as a white solid.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in ether
3. washthe resulting solution was washed with water (3×300 ml) and brine (300 ml)
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure

ORD record

ord-3cb4cbb03df848268457a1bde7ca30b1

Source dataset

uspto-grants-2008_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07435728B2