反应详情

A suspension of selenium dioxide (0.821 g, 7.4 mmol) in 1,4-dioxane (40 mL) and water (3 mL) was heated at 55° C. until selenium dioxide was dissolved. To the solution was added 1-[4-(2-bromoethoxy)phenyl]ethanone (1.80 g, 7.4 mmol), and the reaction was heated to reflux for 4 hours. The reaction was filtered, concentrated, and purified by column chromatography (SiO2, 50% ethyl acetate/hexane) to provide the title compound (1.853 g, 97% yield): ES-MS (m/z) 257 [M+H]+.

1. dissolutionwas dissolved
2. temperaturethe reaction was heated
3. temperatureto reflux for 4 hours
4. filtrationThe reaction was filtered
5. concentrationconcentrated
6. custompurified by column chromatography (SiO2, 50% ethyl acetate/hexane)