HRID2114770

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID135033

2-Pyridinecarbonyl chloride, hydrochloride

C6H5Cl2NO

反应SMILES：COC(=O)c1nc(C2CCc3ccccc3N2)n(C)c(=O)c1OC(=O)c1ccccc1

HCID21098173

未命名化合物

PRODUCTS

产物

反应SMILES：COC(=O)c1nc(C2CCc3ccccc3N2C(=O)c2ccccn2)n(C)c(=O)c1OC(=O)c1ccccc1

HCID17961698

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The residue of Step 1 was dissolved in dichloromethane. Pyridine, picolinoyl chloride hydrochloride and a catalytic amount of DMAP were added. A further addition of the reactants was made after two hours. After evaporation of the solvent, the residue was diluted with EtOAc, the organic phase washed with water, dried (Na2SO4) and evaporated to afford the title product.

WORKUP

后处理

additionA further addition of the reactants
customAfter evaporation of the solvent
additionthe residue was diluted with EtOAc
washthe organic phase washed with water
dry with materialdried (Na2SO4)
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-057000fa4ef841958ce8cc4136a5b9ac
来源数据集: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07435734B2
来源说明: uspto-grants-2008_10

反应SMILES

[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]1[N:12]([CH3:31])[C:13](=[O:30])[C:14]([O:21][C:22](=[O:29])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:15]([C:17]([O:19][CH3:20])=[O:18])[N:16]=1.N1C=CC=CC=1.Cl.[N:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[C:45](Cl)=[O:46]>ClCCl.CN(C1C=CN=CC=1)C>[C:22]([O:21][C:14]1[C:13](=[O:30])[N:12]([CH3:31])[C:11]([CH:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]2[C:45]([C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][N:39]=2)=[O:46])=[N:16][C:15]=1[C:17]([O:19][CH3:20])=[O:18])(=[O:29])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1