反应详情

温度

45 °C

Crude (2,3-difluoro-5-nitrophenyl)acetic acid (16, 1.00 g, 0.00461 mol) and isopropylamine (6 eq., 2.35 ml, 0.0276 mol) are mixed in DMSO (5 ml) and stirred at 45° C. for 1 hour. 2N Hydrochloric acid (20 ml) is added in one portion and the mixture stirred at room temperature for 1 hour. The resulting precipitate is filtered, washed with water and ether, and dried under vacuum (0.39 g, 35%); HPLC r.t. 5.31 min.

1. stirringthe mixture stirred at room temperature for 1 hour
2. filtrationThe resulting precipitate is filtered
3. washwashed with water and ether
4. customdried under vacuum (0.39 g, 35%)