Thionyl Chloride → 3-Bromofuran-2-carbonyl chloride

HRID 2114906Notes

Reaction equation

HRID 2114906 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([OH:9])=O.S(Cl)([Cl:12])=O>>[Br:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([Cl:12])=[O:9]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 6054793-Bromofuran-2-carboxylic acid

Product 1

HCID 218645763-Bromofuran-2-carbonyl chloride

Procedure

Compounds of this invention with Formulae I-IX may be prepared as illustrated by the exemplary reaction in Scheme 2. Reaction of 3-bromo-furan-2-carboxylic acid with thionyl chloride produces intermediate, 3-bromo-furan-2-carbonyl chloride, followed by refluxing with 4-trifluoromethyl-benzamidoxime in pyridine produces the product 5-(3-bromo-furan)-3-(4-trifluoromethyl-phenyl)-[1,2,4]-oxadiazole.

Workup

  1. customCompounds of this invention with Formulae I-IX may be prepared
  2. customas illustrated by the exemplary reaction in Scheme 2

Sources & evidence

ORD record
ord-209a46d3a39a4c428b257bbcc119fb2d
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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