Methyl bromoacetate → HCID 10154914, compound

HRID 2114920Notes

Reaction equation

[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[O:11][N:10]=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[N:8]=1.Br[CH2:20][C:21]([O:23][CH3:24])=[O:22]>>[CH3:24][O:23][C:21](=[O:22])[CH2:20][O:18][C:15]1[CH:14]=[CH:13][C:12]([C:9]2[N:8]=[C:7]([C:3]3[S:4][CH:5]=[CH:6][C:2]=3[Cl:1])[O:11][N:10]=2)=[CH:17][CH:16]=1

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 135433452HCID 135433452, compound

Product 1

HCID 10154914HCID 10154914, compound

Procedure

The title compound was prepared from 4-[5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazol-3-yl]-phenol and methyl bromoacetate by a procedure similar to that of Example 37 as a white solid, (30.3 mg, 52.0%). 1H NMR (DMSO-d6): 8.18 (d, J=5.1 Hz, 1H), 8.00 (d, J=8.7 Hz, 2H), 7.42 (d, J=5.1 Hz, 1H), 7.15 (d, J=9.0 Hz, 2H), 4.90 (s, 2H), 1.2 (m, 3H).

Sources & evidence

ORD record: ord-457d86487e264985811f9c522edd8bb1
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07435750B2

Reaction notes

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