4-(Trifluoromethyl)benzoyl chloride → HCID 22147893, compound

HRID 2114949Notes

Reaction equation

HRID 2114949 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[O:22])[CH2:8][NH:9][C:10](=O)[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1.Cl.ClC1C=CSC=1C(=O)CN.FC(F)(F)C1C=CC(C(Cl)=O)=CC=1>>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[O:22][C:10]([C:11]2[CH:12]=[CH:13][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:15][CH:16]=2)=[N:9][CH:8]=1

Participants

4

Reactant 3

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 22147869HCID 22147869, compoundHCID 692498842-(3-Chloro-thiophen-2-yl)-2-oxo-1-ethylamine hydrochloride

Product 1

HCID 22147893HCID 22147893, compound

Procedure

N-(2-(3-Chloro-thiophen-2-yl)-2-oxo-ethyl]4-trifluoromethyl-benzamide: The title compound was prepared from 2-(3-chloro-thiophen-2-yl)-2-oxo-1-ethylamine hydrochloride and 4-trifluoromethyl-benzoyl chloride by a procedure similar to Example 98a as a white solid (0.044 g, 30%). 1H NMR (DMSO-d6): 9.06 (m, 1H), 7.99 (m, 3H), 7.77 (d, J=8.4 Hz, 2H), 7.20 (d, J=9.0 Hz, 1H), 4.73 (s, 2H).

Sources & evidence

ORD record
ord-81836bc646724b75a22c6c21cd45c864
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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