Methylhydrazine → HCID 22147906, compound

HRID 2114952Notes

Reaction equation

HRID 2114952 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14]3[S:15][CH:16]=[CH:17][C:18]=3[Cl:19])[CH2:9]2)=[CH:4][CH:3]=1.CNN>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14]3[S:15][CH:16]=[CH:17][C:18]=3[Cl:19])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6061MethylhydrazineHCID 22147839HCID 22147839, compound

Product 1

HCID 22147906HCID 22147906, compound

Procedure

5-(4-Chloro-phenyl)-3-(3-chloro-thiophen-2-yl)-1-methyl-4,5-dihydro-1H-pyrazole: The title compound was prepared from 3-(4-chloro-phenyl)-1-(3-chloro-thiophen-2-yl)-propenone (50 mg, 0.176 mmol) and methylhydrazine (9 μL, 0.17 mmol) by a procedure similar to Example 105a as a yellowish oil (20.9 mg, 38%). 1H NMR (CDCl3): 7.24 (m, 4H), 7.09 (d, J=6.6 Hz, 1H), 6.75 (d, J=6.60 Hz, 1H), 4.08 (m, 1H), 3.83 (m, 1H), 2.98 (t, 1H), 2.67 (s, 3H).

Sources & evidence

ORD record
ord-f912a784ebc54548813b276f12e6b9c2
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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