5-Amino-2,3-dihydro-1,3-benzoxazol-2-one → HCID 69100474, compound

HRID 2114964Notes

Reaction equation

HRID 2114964 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=1.[F:12][C:13]1[CH:30]=[CH:29][C:16]([CH2:17][CH:18]2[CH2:23][CH2:22][N:21]([C:24](=[O:28])[C:25](O)=[O:26])[CH2:20][CH2:19]2)=[CH:15][CH:14]=1>O>[F:12][C:13]1[CH:30]=[CH:29][C:16]([CH2:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:28])[C:25]([NH:1][C:2]3[CH:3]=[CH:4][C:5]4[O:9][C:8](=[O:10])[NH:7][C:6]=4[CH:11]=3)=[O:26])[CH2:22][CH2:23]2)=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 268565-Amino-2,3-dihydro-1,3-benzoxazol-2-oneHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

Product 1

HCID 69100474HCID 69100474, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared from 5-amino-3H-benzoxazol-2-one [J. Med. Chem., 10, 408. (1967)] and [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 1b) according to the method described in Example 2. Melting Point: 226-231° C. (water)

Sources & evidence

ORD record
ord-8b6fb5b05fd24801bfa5f1fcd184570e
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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