4-Aminobenzonitrile → HCID 69100519, compound

HRID 2114969Notes

Reaction equation

HRID 2114969 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[F:10][C:11]1[CH:28]=[CH:27][C:14]([CH2:15][CH:16]2[CH2:21][CH2:20][N:19]([C:22](=[O:26])[C:23](O)=[O:24])[CH2:18][CH2:17]2)=[CH:13][CH:12]=1>C(OCC)C>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:23](=[O:24])[C:22]([N:19]2[CH2:18][CH2:17][CH:16]([CH2:15][C:14]3[CH:13]=[CH:12][C:11]([F:10])=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)=[O:26])=[CH:3][CH:4]=1)#[N:7]

Participants

4

Reactant 2

HCID 133964-AminobenzonitrileHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

Product 1

HCID 69100519HCID 69100519, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 4-amino-benzonitrile and [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 1b) according to the method described in Example 1c. Melting Point: 167-169° C. (diethylether)

Sources & evidence

ORD record
ord-20c77088a00c4e1790632b3be066dd24
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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