3-Aminobenzonitrile → N-(3-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl)-2-oxo-acetamide

HRID 2114973Notes

Reaction equation

HRID 2114973 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:17])[C:14]([OH:16])=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[C:24]#[N:25]>C(OCC)C>[C:24]([C:23]1[CH:22]=[C:21]([NH:20][C:14](=[O:16])[C:13]([N:10]2[CH2:9][CH2:8][CH:7]([CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[O:17])[CH:28]=[CH:27][CH:26]=1)#[N:25]

Participants

4

Reactant 2

HCID 167023-AminobenzonitrileHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

Product 1

HCID 69100240N-(3-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl)-2-oxo-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 1b) and 3-aminobenzonitrile (Aldrich) according to the method described in Example 1c. Melting Point: 135-138° C. (diethylether)

Sources & evidence

ORD record
ord-056c94fc2e1c47b094430ba863a0e9a4
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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